Endocrine Abstracts

Background and aims: Growth hormone and insulin-like growth factors to be involved in the pathogenesis of diabetic kidney disease. The aim of this study was ultrastructural evaluation of octreotide acetate on kidney tissue in streptozotocin (STZ) induced diabetic rats.Material and methods: Twenty-four male Spraque–Dawley rats divided into 3 groups; control (C), diabetic (D) and diabetic with octreotide aceatate (DO). The all diabetic rats were treat...

Background and aim: C-reactive protein (CRP) is a sensitive marker for systemic inflammation. In this study we aimed to investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and BMI, body fat mass and fat distribution in healthy subjects.Subjects and methods: A total 117 healthy subjects aged with 20–68 yr [normal weight (BMI 18.5–25.0 kg/m2, n:35), overweight (BMI: 25–30 kg/m2</sup...

Background and aim: Carotid intima-media thickness (IMT), as assessed by B-mode ultrasound, is a commonly used clinical marker that reflects systemic burden of atherosclerosis and value of IMT at or above 1 mm at any age is associated with a significantly increased risk of myocardial infarction. On the basis of such findings, we aimed to clarify the relationship between carotid intima-media thickness and anthropometric and metabolic parameters in virtually healthy subjects.</p...

Background and aim: It was known that NT-proBNP levels increased in cardiac failure. But, NT-proBNP levels in different thyroid status still unclear. We aimed to evaluate serum NT-proBNP levels in both of hyperthyroid and hypothyroid patients without cardiac insufficiency.Subjects and methods: Thirty nine patients with hyperthyroidism (43.0±16.5 yr), 25 patients with hypothyroidism (35.4±13.9 yr) and 34 ages matched euthyroid subjects (41.4&#17...

Background and aim: Somatostatin analogues such as octreotide acetate were used in acromegalic patients as primary or secondary treatment. In this study we aimed to report completely disappearing of adenoma and clinical cure in 3 acromegalic cases that rejected surgical treatment.Case1: E.A (62 years old, female) She reported enlargement of his hands, deepening of his voice and increases in shoe size. MRI revealed a macro adenoma which was spread to cave...

Background and aim: Hyperprolactinemia may associate with insulin resistance. This fact has been determined by many studies with methods which show insulin sensitivity. In this study we aimed to search insulin resistance with golden standard euglycemic hyperinsulinemic clamp technique on hyperprolactinemic patients.Subjects and methods: This study was performed in Endocrinology Department of Dicle University. Sixteen patients with microprolactinoma (mean...

Aim: Sheehan‘s syndrome (SS) remains a frequent cause of hypopituitarism in undeveloped and developing countries, but due to improvements in obstetric care, it is rare in developed countries. We aimed to share the results of a retrospective study analyzing the demographic, clinical, imaging, and hormonal characteristics of a large group of patients with SS, and also increase awareness of this syndrome especially in developed countries.Methods: The m...

Objective: In this study we aim to investigate the association of osteoporosis and type 1 diabetes in 43 type 1 diabetic subjects and 41 control subjects.Subjects and methods: Bone mineral density of both groups was measured by DEXA. Age, BMI, waist/hip ratio, daily calcium consumption of both groups were determined. Twenty-four hours urinary calcium, phosphorus, deoxipyridinoline and pyridinoline were measured. Osteocalcin ALP, IGF-1, IBF-BP3. HbA1c, co...

Aim: To examine the endothelial functions of patients with Sheehan syndrome (SS) and to eveluate the effects of hormone replacement treatment except growth hormone on endothelial functions.Subjects and methods: Twenty-four patients with Sheehan syndrome (PSS) aged 40.83±6.43 yr and 25 healthy control women aged 41.13±6.51 yr (C) were included. Endothelial functions were evaluated with high resolution ultrasonography (flow mediated dilatation:FM...

Context: The prevalence of NCAH among Turkish women with hirsutism has not been established so far.Objective: To evaluate the prevalences of 21-hydroxylase (21-OHD) and 11-β hydroxylase deficiencies by ACTH stimulation test among hirsute women.Patients and methods: The study population consisted of 285 premenopousal women, aged 16–46 years (mean: 23.2±0.3). All were hirsute and hyperandrogenic. Androgen secreting tum...